You probably don't want to do this, since auto-saving is useful, especially when Emacs or your computer crashes while you are editing a document.
Instead, you might want to change the variable
auto-save-interval, which specifies how many keystrokes Emacs
waits before auto-saving. Increasing this value forces Emacs to wait
longer between auto-saves, which might annoy you less.
You might also want to look into Sebastian Kremer's
package (see Packages that do not come with Emacs). This
package also allows you to place all auto-save files in one directory,
such as /tmp.
To disable or change how
see Auto Save.